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Lichenoid Drug Eruptions due to Nandrolone Furylpropionate (Demelon)®
Author(s) -
Aihara Michiko,
Kitamura Kazuko,
Ikezawa Zenro
Publication year - 1989
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1989.tb01274.x
Subject(s) - erythema , medicine , dermatology , drug eruption , reticular connective tissue , lesion , pathology , erythema multiforme , peripheral blood mononuclear cell , biopsy , drug , chemistry , pharmacology , biochemistry , in vitro
A case of lichenoid drug eruption due to nandrolone furylpropionate (Demelon®) is reported. A 71‐year‐old man with aplastic anemia developed widespread erythema and reticulation with violaceous papules and pigmentation after receiving intramuscular injections of Demelon weekly for 2 months. The eruption gradually resolved after drug withdrawal, leaving reticular pigmentation. A biopsy specimen of the skin lesion showed lichenoid‐type reactions including hydropic or colloid degeneration of the basal cells, sometimes with satellite necrosis, and a band‐like subepidermal lymphocytic infiltrate. Most of the mononuclear cells stained strongly for helper/inducer T lymphocytes (Leu 3a).