Premium
Hyperresponsibility to Exogeneous Interleukin 4 in Atopic Dermatitis
Author(s) -
Furue Masutaka,
Ogata Fuyuki,
Ootsuki Mamitaro,
Ishibashi Yasumasa
Publication year - 1989
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1989.tb01258.x
Subject(s) - atopic dermatitis , immunoglobulin e , immunology , immune system , interleukin 4 , interleukin , receptor , interleukin 2 , humoral immunity , peripheral blood , medicine , biology , antibody , cytokine
Many humoral and cellular immunological abnormalities have been reported in atopic dermatitis (AD). Since interleukin 4 (IL‐4) enhances IgE production and IgE‐Fc receptor expression by B cells as well as [ 3 H]‐TdR incorporation by T cells, we hypothesized that IL‐4 may play an important role in the regulation of the immune response in AD. We examined [ 3 H]‐TdR incorporation by peripheral blood lymphocytes from AD patients or from non‐AD controls in the presence or absence of IL‐4 or interleukin 2 (IL‐2). We found that IL‐4/IL‐2 responsiveness was significantly higher in AD than controls, although the IgE levels did not seem to be correlated with IL‐4/IL‐2 responsiveness. It is possible that most humoral and cellular immunological abnormalities of AD may be due to this hyperresponsibility to IL‐4