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Investigation of the Roles of the Substances in Serum Lipids and Their Constitutive Fatty Acids in Chronic Urticaria
Author(s) -
Kobayashi Sumiko
Publication year - 1989
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1989.tb01249.x
Subject(s) - polyunsaturated fatty acid , arachidonic acid , chronic urticaria , lipid metabolism , lipid peroxidation , glutathione , chemistry , metabolism , arachidonic acid metabolism , endocrinology , fatty acid , medicine , biochemistry , antioxidant , enzyme
Abstract The newly‐generated lipid mediators include products of arachidonate metabolism, prostaglandins and leukotrienes. In this study, serum lipids and fatty acids, including arachidonic acid (C20:4) were examined in 12 normal subjects (6 males and 6 females) and 23 subjects with chronic urticaria (6 males and 17 females), including 17 who made an excellent or good recovery (4 males and 13 females). The results indicated a relationship between chronic urticaria and serum lipids and fatty acids. The ω 6 (n‐6) and ω 3 (n‐3) series of polyunsaturated fatty acids and lipid peroxidation were suggested that may be one of the mediators in chronic urticaria. Pantethine, glutathione and ascorbic acid were effective in controlling chronic urticaria.