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IL‐1 and PGE 2 Productions by the Regional Lymph Node Cells from DNFB‐sensitized Mice
Author(s) -
Natsuaki Masaru,
Higasa Minoru,
Sagami Seiichiro,
Shinka Sohei
Publication year - 1989
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1989.tb01231.x
Subject(s) - macrophage , lymph node , lymph , cytokine , immunology , in vitro , stimulation , prostaglandin e2 , chemistry , interleukin 10 , biology , microbiology and biotechnology , medicine , endocrinology , pathology , biochemistry
Interleukin 1 (IL‐1) and Prostaglandin E 2 (PGE 2 ) are mainly produced by macrophage/monocytes. In this experiment, we investigated the immunological role of macrophage/monocytes in the lymph nodes (LNs) by measuring IL‐1 and PGE 2 productions of regional LN cells from dinitrofluorobenzene (DNFB)‐sensitized and ‐tolerant mice. LN cells from sensitized mice produced IL‐1 in remarkable amounts after in vitro antigen stimulation. On the other hand, the LN cells from tolerant mice failed to produce IL‐1 or PGE 2 . These data indicate that, by modifying cytokine production, macrophage/monocytes in the regional LNs play a key role in the pathomechanism of contact hypersensitivity.