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Glycosylated Proteins of Skin, Nail and Hair: Application as an Index for Long‐term Control of Diabetes Mellitus
Author(s) -
Sueki Hirohiko,
Nozaki Shigeyuki,
Fujisawa Ryuichi,
Aoki Kimiko,
Kuroiwa Yukio
Publication year - 1989
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1989.tb01230.x
Subject(s) - nail (fastener) , diabetes mellitus , index (typography) , medicine , term (time) , dermatology , endocrinology , computer science , engineering , world wide web , mechanical engineering , physics , quantum mechanics
The purpose of the present study was to compare the degrees of nonenzymatically glycosylated proteins in the skin (stratum corneum), the nail, the hair, and hemoglobin obtained simultaneously from the same subject and to evaluate the most useful sample for management of diabetic complications. Fifty‐one diabetic patients and 20 control patients were examined, utilizing furosine determination. Furosine value of the skin in diabetics was 2.14 ± 1.70%, whereas that in controls was 1.65 ± 0.47%. Furosine value of the nail in diabetics was 6.67 ± 3.30%, whereas that in controls was 4.16 ± 1.62%. Furosine value of the hair in diabetics was 1.30 ± 1.11%, whereas that in controls was 1.29 ± 1.71%. Close correlations were detected between HbA 1 (glycosylated hemoglobin) and furosine of the nail (r=0.58, p<0.001), HbA 1 and furosine of the skin (r=0.48, p<0.001), and HbA 1 and furosine of the hair (r=0.43, p<0.01); however, poor correlations were found between furosine of the hair and the skin (r=0.35, p<0.05) and furosine of the nail and the hair (r=0.33, p<0.05). Furosine of the nail was significantly correlated with the FBS (fasting blood sugar) of the same time, previous 6, and previous 12 months. Furosine value of the nail, we believe, is the most useful indicator for evaluating long term control of diabetics and may provide useful information for management of diabetic complications.