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Electrophoretic Mobility of Polymorphonuclear Leukocytes Response to Scale Extracts from Psoriasis Vulgaris
Author(s) -
Higuchi Mitsunari
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb04071.x
Subject(s) - electrophoresis , psoriasis , polymorphonuclear leukocyte , chemistry , in vitro , incubation , cell , callus , immunology , biochemistry , medicine , biology , botany
The cell electrophoretic mobility of polymorphonuclear leukocyte responses to scale extracts from psoriasis vulgaris and other dermatoses (callus and pompholyx) was determined by analytical free‐flow cell electrophoresis technique. Incubation with scale extracts from psoriasis significantly reduced the electrophoretic mobility of polymorphonuclear leukocytes compared with those from callus and pompholyx; ultrafiltrated scale extracts separated 10,000–30,000 d showed the highest reduction. Pretreatment of polymorphonuclear leukocytes with etretinate in vitro blocked reduction of the cell electrophoretic mobility. It is concluded that psoriatic scale extracts contain factor(s) which reduce the charge density of polymorphonuclear leukocytes and that this reduction is inhibited by etretinate pretreatment.