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Pigmented Macules in Patients Treated with Systemic 5‐Fluorouracil
Author(s) -
Cho Kwang Hyun,
Chung Jin Ho,
Lee Ai Young,
Lee Yoo Shin,
Kim Noe Kyung,
Kim Chul Woo
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb03706.x
Subject(s) - melanin , fluorouracil , melanocyte , epidermis (zoology) , dermatology , pigmentation disorder , chemotherapy , incidence (geometry) , medicine , cancer research , biology , melanoma , anatomy , biochemistry , physics , optics
Pigmented macules were observed in 72 (52.6%) out of 137 patients treated with systemic 5‐fluorouracil. These pigmented macules usually appeared on the palms and the soles. Their incidence seemed to be proportional to the number of chemotherapy cycles. Histological studies showed a slight increase in melanin pigmentation in the epidermis without any change in the melanocyte number. This suggests that the melanocytes already present produced quantities of melanin.