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Serum Lipid Peroxide Levels in Various Dermatoses
Author(s) -
Demitsu Toshio,
Katayama Hiroshi,
Yaoita Hideo
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb03702.x
Subject(s) - lipid peroxide , medicine , thiobarbituric acid , dermatology , prurigo , lipid peroxidation , atopic dermatitis , psoriasis , acne , pathogenesis , immunology , oxidative stress
In studies of physiological roles of lipid peroxide in cutaneous tissue, we examined serum lipid peroxide levels in 199 patients with various dermatoses such as psoriasis, eczema/prurigo, alopecia, bullous disorders, acne/seborrheic dermatitis, atopic dermatitis, SLE, urticaria, progressive systemic sclerosis, generalized morphea, and herpes zoster, by using the TBA (thiobarbituric acid) method and a new assay technique, called the MCDP (methyl carbamoyl‐dimethylamino phenothiazine)‐Hb method. The following results were obtained. By the TBA method, statistically significantly high serum lipid peroxide levels were noted in patients with psoriasis, eczema/prurigo, alopecia, SLE and generalized morphea. By the MCDP‐Hb method, similarly high levels were found in patients with alopecia and atopic dermatitis, compared with those of the control group. The discrepancy between the results from the TBA and the MCDP‐Hb methods is thought to be due to the fact that TBA method measures a secondary product of lipid peroxide, malondialdehyde, whereas the MCDP‐Hb method measures lipid hydroperoxide itself. These results suggest some involvement of lipid peroxidation in the pathogenesis or, at least, in the enhancement and modification of the symptoms in these dermatoses.