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Administration of IgG Fraction of Epidermolysis Bullosa Acquisita (EBA) Serum into Mice
Author(s) -
Shigemoto Takashi,
Nashiro Kiyoko,
Tsuchida Tetsuya,
Seki Yoshihito,
Tamaki Kunihiko
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb03663.x
Subject(s) - epidermolysis bullosa acquisita , pathogenesis , medicine , fetus , subcutaneous injection , epidermolysis bullosa , autoantibody , endocrinology , antibody , immunology , pathology , biology , pregnancy , genetics
In order to study the pathogenic role of autoantibodies in the serum of EBA patients, we tried to induce EBA lesions in mice by administration of the IgG fraction of EBA serum via the intraperitoneal (i.p.) or subcutaneous (s.c.) routes into neonatal or adult mice. We also tried to induce EBA lesions in fetuses by intravenous (i.v.) injection of EBA serum into pregnant mice. This study demonstrates that IgG fraction of EBA serum injected into neonatal or adult mice, but not into fetal mice, deposits at the epidermo‐dermal junction in a linear fashion but fails to induce bullae. The role of EBA serum in the pathogenesis of EBA lesions is discussed.