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The Mechanism of the Inhibitory Effects of Antimalarials on UV‐induced Skin Inflammation in Mice
Author(s) -
Yoshioka Akira,
Miyachi Yoshiki,
Imamura Sadao
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb03661.x
Subject(s) - arachidonic acid , phospholipase a2 , inflammation , chemistry , pharmacology , methoxsalen , psoriasis , puva therapy , inhibitory postsynaptic potential , phospholipid , biochemistry , immunology , medicine , membrane , enzyme , endocrinology
In order to elucidate the mechanism of UV‐induced skin inflammation, the effects of antimalarials, inhibitors of phospholipase A 2 and membrane phospholipid methylation, on UV‐induced ear swelling response (ESR) was examined. Antimalarials inhibited ESR induced by 8‐methoxypsoralen (0.5%) plus UVA irradiation (PUVA treatment) or UVB irradiation. However, they did not inhibit ESR induced by the application of arachidonic acid (AA). Although it has been reported that PUVA treatment and UVB irradiation may work through different AA pathways, it seems likely that both PUVA and UVB may affect the initial cellular metabolism of the inflammatory process.