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Eosinophil Chemotactic Activity of Collagen‐derived Fragments
Author(s) -
Isoda Midori
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb03655.x
Subject(s) - collagenase , chemotaxis , eosinophil , chemistry , guinea pig , microbial collagenase , immunology , microbiology and biotechnology , biochemistry , biology , enzyme , endocrinology , receptor , asthma
Eosinophil and neutrophil chemotactic activities of some collagens and their collagenase‐digested fragments were measured by using a Boyden chamber method. Fragments released from bovine dermal collagen and type III collagen derived from calf skin showed chemotactic activity for guinea pig eosinophils in a dose‐dependent manner, but collagen itself did not. Fragments released from bovine dermal collagen also showed chemotactic activity for human neutrophils. Gel filtration study indicated that some sizes of this collagenase‐digested fragments had chemotactic activities for eosinophils. These results suggest that collagen‐derived fragments may play a role in tissue eosinophilia in some inflammatory lesions.