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Cutaneous Angioma in Crow‐Fukase Syndrome: The Nature of Globules within the Endothelial Cells
Author(s) -
Jitsukawa Kumiko,
Hayashi Yoko,
Sato Syozo,
Anzai Takashi
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb01201.x
Subject(s) - pathology , chemistry , immunohistochemistry , electron microscope , angioma , endothelium , biology , medicine , vascular disease , physics , optics , endocrinology
To clarify the nature of the intracytoplasmic globules seen in the endothelial cells of the cutaneous angiomas of the Crow‐Fukase syndrome, we performed light and electron microscopic as well as immunohistochemical studies. The proliferating plump endothelial cells of the angioma located in the mid‐dermal portion contained numerous globules. IgG, A, M, and kappa and lambda light chain globulins were present in the endothelial cells containing these globules. Electron microscopy revealed osmiophilic fine fibrillar structures and amorphous substance in the globules. Thiéry staining for detection of vicinal‐glycol radicals of carbohydrate demonstrated the deposition of fine silver particles as a reaction product. We consider that the intracytoplasmic globules are phagolysosomes containing glycoprotein.