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Monocyte Activating Factor Originally Found in Sarcoidosis Sera
Author(s) -
Baba Toru,
Matsushima Yuji,
Onozaki Kikuo,
Baba Akiko,
Uyeno Kenichi
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb01198.x
Subject(s) - monocyte , immunology , chemistry , receptor , endocrinology , medicine
The culture medium for normal human monocytes pretreated with interleukin (IL)‐1, either α and β, induced normal human monocytes to spread and to increase Fc (IgG) receptor sites, angiotensin converting enzyme production and glucose consumption of normal human monocytes, suggesting that this medium contains a monocyte activating factor(s). On TSK G3000SW gel filtration, the major monocyte activating factor in the culture medium and that in sarcoidosis serum were eluted at the same position (with a molecular weight of about 70,000). Thus, IL‐1 may be able to induce normal human monocytes to produce a monocyte activating factor quite similar to that found in sarcoidosis serum.