Premium
Epidermal Basement Membrane Alterations in Epidermolysis Bullosa Acquisita
Author(s) -
Miyagawa Sachiko,
Shirai Toshihiko,
Matsumoto Hirohito,
Komatsu Machiko,
Iida Takashi,
Sakamoto Kuniki
Publication year - 1988
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1988.tb01197.x
Subject(s) - epidermolysis bullosa acquisita , lamina densa , basement membrane , pathology , lamina lucida , lesion , epidermolysis bullosa , medicine , cicatricial pemphigoid , type iv collagen , dermatology , chemistry , ultrastructure , cell , immunology , pemphigoid , bullous pemphigoid , laminin , basal lamina , antibody , biochemistry
Immunopathological studies on a patient with clinical evidence of epidermolysis bullosa acquisita (EBA) revealed an increase in type IV collagen in the skin of the chronic scarred lesion, but not in the clinically normal skin. These findings, together with multiplication of the lamina densa of the chronic lesional skin demonstrated by electron microscopy, strongly suggest that repeated injury possibly stimulates epidermal cells to secrete type IV collagen, leading to multiplication of lamina densa of the basement membrane at the dermal‐epidermal junction in EBA.