Premium
Leukocyte Chemotactic Activity and Circulating Immune Complexes in Psoriasis
Author(s) -
Isoda Midori
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb03629.x
Subject(s) - chemotaxis , immune system , psoriasis , immunology , polyethylene glycol , medicine , immune complex , chemistry , receptor , biochemistry
The sera of 12 patients with psoriasis vulgaris were studied for immune complexes using the polyethylene glycol (PEG) assay. Thirty three percent of sera had elevated levels of immune complexes. Neutrophil chemotactic activity of these sera was compared to the sera of healthy controls and psoriatic patients who showed low levels of immune complexes, using a Boyden chamber method. Neutrophil chemotaxis of these patients with high levels of immune complexes was decreased below that of healthy controls or patients who showed low levels of immune complexes. These results suggest that circulating immune complexes of psoriatic patients may be associated with the defect of chemotaxis in this disease.