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A Monoclonal Anti‐keratin Antibody Reactive with Amyloid Deposit of Primary Cutaneous Amyloidosis
Author(s) -
Kitano Yukio,
Okada Natsuko,
Kobayashi Yoichi,
Tanigaki Takehiko,
Okano Masaki,
Yoshikawa Kunihiko
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb03604.x
Subject(s) - keratin , monoclonal antibody , amyloidosis , amyloid (mycology) , pathology , chemistry , stain , antibody , epidermis (zoology) , monoclonal , microbiology and biotechnology , biology , staining , immunology , medicine , anatomy
Specimens from cutaneous amyloidoses (lichen amyloidosis and macular amyloidosis) were stained immunohistochemically with monoclonal anti‐keratin antibodies. One monoclonal antibody raised against hair keratin (HKN‐6) reacted with the amyloids of both primary amyloidoses. Another monoclonal antibody, HKN‐2, did not decorate the amyloid deposit. HKN‐6 did not stain the interfollicular epidermis, but HKN‐2 did. The possible explanations of these findings are 1) amyloid deposits contain keratin protein modulated to react with HKN‐6; 2) amyloid deposits contain a protein unrelated to keratin protein, but reactive to HKN‐6.