Biochemical Study of Fecal Porphyrin in Porphyria Cutanea Tarda | Zendy

aka Shigeo | Zendy; Ohgami Taro | Zendy; Murayama Fumio | Zendy; Yamashita Kazunori | Zendy; Nagato Nori | Zendy; Watanabe Masahisa | Zendy; Irifune Hiroko | Zendy; Yoshida Hikotaro | Zendy

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Biochemical Study of Fecal Porphyrin in Porphyria Cutanea Tarda

Author(s) -

aka Shigeo,

Ohgami Taro,

Murayama Fumio,

Yamashita Kazunori,

Nagato Nori,

Watanabe Masahisa,

Irifune Hiroko,

Yoshida Hikotaro

Publication year - 1987

Publication title -

the journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.9

H-Index - 65

eISSN - 1346-8138

pISSN - 0385-2407

DOI - 10.1111/j.1346-8138.1987.tb03581.x

Subject(s) - porphyrin , feces , porphyria cutanea tarda , excretion , porphyria , protoporphyrin , urine , chemistry , medicine , urinary system , gastroenterology , endocrinology , biochemistry , biology , microbiology and biotechnology

Fecal, urinary and erythrocyte porphyrin analyses using the solvent extraction method were performed in 26 patients with porphyria cutanea tarda (PCT) and 144 normal controls. The levels of fecal uroporphyrin (UP) and coproporphyrin (CP) were markedly increased in the PCT group, especially in comparison with the protoporphyrin (PP) level. The values of the UP/PP and CP/PP ratios in the feces were also elevated over those in the control group. It appears that fecal porphyrin excretion is basically similar to urinary porphyrin excretion in PCT. The analysis of fecal porphyrins and the observation of fecal UP/PP and CP/PP ratios may be helpful in the biochemical diagnosis of PCT. In particular, the elevation of CP/PP ratio is characteristic of PCT.

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