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Genital Paget's Disease: A Histological Study of the Tumor Margin
Author(s) -
Sano Yutaka,
Sakuma Hideo,
Hara Tohru,
Saeki Hideaki,
Sugawara Mitsuo,
Tasaki Michiko,
Sato Shizuo,
Ito Izumi
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb03577.x
Subject(s) - infiltration (hvac) , medicine , anus , lesion , sex organ , resection , biopsy , margin (machine learning) , depigmentation , pathology , cellular infiltration , dermatology , anatomy , surgery , biology , physics , genetics , machine learning , computer science , thermodynamics , inflammation
The lesion of genital Paget's disease usually shows pigmentation, depigmentation, erosion and tumor formation. Skin surrounding the lesion looks normal macroscopically. We call this junction between the resion and surrounding skin the macroscopic margin. The mapping of 3 male cases of genital Paget's disease showed complicated infiltration patterns on the skin surface. We classified these infiltration patterns into 3 types. From a study of preparations according to this classification, we found the recommendable to make a wide excision of the tumor, including the surrounding area reaching more than 3 to 5 cm from the macroscopic margin, since this margin is not reliable in deciding the optimal extent of resection. Moreover, it is recommended that unnecessary resection should be avoided by performing close biopsy preoperatively, especially when there is infiltration around the anus, and that histological examination of the whole margin of the resected tissue be made.