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Drug Eruption Caused by Nitrazepam in a Patient with Severe Pustular Psoriasis Successfully Treated with Methotrexate and Etretinate
Author(s) -
Shoji Akinobu,
Kitajima Jun'ichi,
Hamada Toshio
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb03576.x
Subject(s) - etretinate , methotrexate , medicine , nitrazepam , dermatology , psoriasis , pustular psoriasis , rash , drug , drug eruption , provocation test , pharmacology , surgery , pathology , diazepam , alternative medicine
An allergic drug eruption due to nitrazepam was reported in a patient who had been administered methotrexate and etretinate as concurrent therapies for severe pustular psoriasis. The clinical manifestation included a moon face‐like appearance with edema, a diffuse erythematous rash over almost the entire body the day after taking nitrazepam and, two days later, eroded lesions developing on the cheeks, axillae and genitocrural regions. It was proved by provocation that this drug eruption had an allergic nature.