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A Case of Cutaneous Involvement by Sinus Histiocytosis with Massive Lymphadenopathy
Author(s) -
Aso Miki,
Hagari Yoshitaka,
Shimao Shuhei,
Kimura Ryoichi,
Shimizu Yasuyuki
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb03571.x
Subject(s) - histiocyte , sinus histiocytosis with massive lymphadenopathy , pathology , lesion , medicine , histiocytosis , immunohistochemistry , sinus (botany) , rosai–dorfman disease , biology , disease , botany , genus
A 44‐year‐old woman developed an erythematous indurative plaque and papules on the right scapular region. Histological and ultrastructural findings were consistant with sinus histiocytosis with massive lymphadenopathy. However, lymphadenopathy was not demonstrated clinically and the lesion was limited to the skin. Immunohistochemical study showed that histiocytes were positive for S 100 protein and weakly positive to negative for lysozyme. We consider that the histiocytes in this cutaneous lesion of sinus histiocytosis with massive lymphadenopathy are “T‐zone histiocytes” and related to an immunoreaction to unknown antigens.