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Eosinophil Chemotactic Activity of β‐galactosidase
Author(s) -
Isoda Midori
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb03547.x
Subject(s) - eosinophil , chemotaxis , in vitro , in vivo , chemistry , eosinophil cationic protein , granulocyte , immunology , biochemistry , pharmacology , biology , asthma , microbiology and biotechnology , receptor
The chemotactic activity of β‐galactosidase from bovine liver for eosinophils was evaluated in vitro and in vivo. In vitro , the activity increased in a dose‐dependent manner. The maximal activity was detected at the concentration of 0.1 mg/ml. In vivo , at concentrations greater than 0.5 mg/ml, eosinophil chemotactic responses were clearly seen. These results suggest that β‐galactosidase, one of the acid hydrolases, may play a role in eosinophil accumulation in various inflammatory lesions.