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Rabbit Zosteriform Eruption Induced by Intra‐arterial Inoculation of Herpes Simplex Virus, Type 1
Author(s) -
Matsubara Motoo,
Kishimoto Saburo,
Yasuno Hirokazu,
Sotomatsu Shigetaro,
Yoshioka Akira,
Tanaka Atsuo,
Ueda Keiichi,
Ohashi Masami
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb03545.x
Subject(s) - herpes simplex virus , inoculation , lesion , antibody , virology , neutralizing antibody , virus , immunofluorescence , biology , medicine , pathology , immunology
Seventeen rabbits were inoculated with 0.1 ml of herpes simplex virus (HSV), type 1, Miyama strain (10 5,75 TCID 50 /0.1 ml), via the auricular artery; twelve of them developed zosteriform eruptions (ZE) on the skin. Seven rabbits treated with control medium showed no eruptions. This phenomenon was significant (P<0.01). ZE was observed about 7 days (mean time: 7.4 days) after inoculation. Although HSV antigen was found in dorsal root ganglia, spleen and liver by an immunofluorescence method, it was not detectable in the skin lesion. IgG, M and C 3 were also undetectable in the skin lesion. On the other hand, complement requiring neutralizing antibody (CRN‐Ab) against HSV was detected on the 6th day after inoculation. Conventional neutralizing antibody was found on the 9th day after inoculation, but interferon could not be detected during the experimental period. The pathogenesis of ZE was discussed.