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Annular Elastolytic Giant Cell Granuloma: An Unusual Case with Lesions Arising in Non‐sun‐exposed Areas
Author(s) -
Muramatsu Tsutomu,
Shirai Toshihiko,
Yamashina Yukio,
Sakamoto Kuniki
Publication year - 1987
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1987.tb02996.x
Subject(s) - histiocyte , pathology , immunoperoxidase , giant cell , cytoplasm , phagocytosis , staining , pathogenesis , cell , granuloma , chemistry , medicine , biology , immunology , antibody , microbiology and biotechnology , biochemistry , monoclonal antibody
A 70‐year‐old man with a 2‐year history of annular elastolytic giant cell granuloma associated with diabetes mellitus was reported. The lesions mainly developed in non‐sun‐exposed areas. Histologic examination revealed phagocytosis of elastic fibers by histiocytic cells. Immunoperoxidase staining for lysozyme disclosed positive reactivity within the cytoplasm of these histiocytic cells. Electron microscopic study also showed elastic fibers and numerous lipid‐like substances in the cytoplasm of these cells. These findings indicate high phagocytolytic activity by these infiltrating cells. In our case, actinic damage was not considered to be a primary causative factor, and a possible pathogenesis was also discussed.