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Protein AL Origin in Amyloidosis Cutis Nodularis Atrophicans
Author(s) -
Masuda Chieko,
Hayashi Masayuki,
Kameda Yo,
Mohri Shinobu,
Nakajima Hiroshi,
Nagai Ryukichi
Publication year - 1986
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1986.tb02941.x
Subject(s) - amyloidosis , antibody , immunoglobulin light chain , chemistry , amyloid (mycology) , pathology , biology , immunology , medicine
A case of amyloidosis cutis nodularis atrophicans (ACNA) was reported. The characteristics of the amyloid deposit were examined using the unlabeled immunoperxoidase method (peroxidase‐antiperoxidase method, so called PAP). The study revealed that the amyloid deposit contained A type protein AL, and the surrounding plasma cells contained λ and κ types of both immunoglobulin light chains and Bence Jones protein, with strong preference toward the λ type of each protein. These results suggest that, in ACNA, the plasma cells produce and secrete immunoglobulin light chains and/or Bence Jones protein, and that the protein degenerates into protein AL and then accumulates in the tissue to form nodules. ACNA seems to be a localized form of AL type amyloidosis, since patients with ACNA have no signs of systemic involvement.