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Increased C5a Anaphylatoxin in the Sera of Psoriatic Patients and Patients with Inflammatory Dermatoses
Author(s) -
Ohkohchi Kyoko,
Takematsu Hideaki,
Tagami Hachiro
Publication year - 1986
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1986.tb02939.x
Subject(s) - anaphylatoxin , psoriasis , medicine , radioimmunoassay , immunology , complement system , dermatology , complement (music) , inflammation , complement component 5 , antibody , chemistry , biochemistry , phenotype , complementation , gene
We measured C5a and C5a des arg (collectively called C5a) by radioimmunoassay in the sera of psoriasis and other widespread inflammatory dermatoses. Larger amounts of serum C5a were detected in patients with psoriasis and other inflammatory dermatoses than in normal healthy controls. In the psoriatic patients, the serum C5a concentrations did not correlate with extent or with activity of the skin lesions. However, when followed in 6 psoriatic patients, the C5a levels showed changes in parallel with the skin lesions. Our results suggest that complement activation with resultant release of C5a anaphylatoxin takes place in psoriasis as well as in other widespread inflammatory skin disorders.