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A Case of Extensive Subcutaneous Sarcoidosis
Author(s) -
Yamada Saori,
Yagi Ayako,
Shiraishi Satoshi,
Miki Yoshiharu
Publication year - 1986
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1986.tb02930.x
Subject(s) - medicine , pericardial effusion , sarcoidosis , epithelioid cell , pleural effusion , angioedema , edema , pathology , subcutaneous injection , immunohistochemistry
A 61‐year‐old female with extensive subcutaneous epithelioid cell granuloma in the back and extremities had negative tuberculin reaction, positive anti‐nuclear factor (ANF) and elevated serum angiotensin‐converting enzyme (ACE) level while on oral clofibrate for one‐and‐a‐half years because of hyperlipemia. She also suffered from ischemic heart disease with pericardial effusion and dependent edema. The skin surface temperatures over the lesions were about 2°C higher than those of the surrounding normal skin. The subcutaneous lesions cleared spontaneously within 4 months after clofibrate was discontinued. Tuberculin reaction became positive and serum ACE returned to the normal level.