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Immunohistochemical and Electron Microscopic Observations in Granular Cell Tumors
Author(s) -
Kishimoto Saburo,
Arita Tsugihisa,
Koishi Kazuo,
Hirano Shinya,
Ikada Junji
Publication year - 1986
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1986.tb02910.x
Subject(s) - s100 protein , pathology , immunohistochemistry , electron microscope , cytoplasm , glial fibrillary acidic protein , myelin , staining , myelin basic protein , schwann cell , biology , negative stain , vacuole , chemistry , microbiology and biotechnology , medicine , central nervous system , neuroscience , physics , optics
Two cases of granular cell tumor (GCT) of the skin were examined immunohistochemically for the presence of S‐100 protein (S100), myelin basic protein (MBP), glial fibrillary acidic protein (GFA), serotonin, and B‐2‐microglobulin (B2M). One of the tumors was also observed by electron microscopy. The tumor cells in both cases showed positive staining for S100 and B2M. Although immunoreactive MBP was not found in the tumor cells, it was observed in the nerve fascicles and the nerve fibers in the stroma. Staining for GFA and serotonin was negative. The electron microscopic findings showed that a large number of the tumor cells appeared to be in the final stage, showing structureless cytoplasm with various granules and vacuoles. Since S100 appears to be a marker for Schwann cells, the expression of S100 by GCT supports its neural genesis.