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The Inhibitory Effect of Selenium on Mice Inoculated with B16 Melanoma Cells
Author(s) -
Hanada Katsumi,
Satoh Shizuo,
Sawamura Daisuke,
Hashimoto Isao,
Katabira Yasuo
Publication year - 1986
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1986.tb02894.x
Subject(s) - selenium , melanoma , in vivo , in vitro , cell growth , chemistry , cancer research , inoculation , inhibitory postsynaptic potential , biology , immunology , biochemistry , endocrinology , genetics , organic chemistry
The influence of selenium dioxide on the in vitro and in vivo growth of transplantable B16 melanoma was studied. In the in vivo study, melanoma tissues showed a decrease in development of tumor growth and a tendency toward higher levels of free radical signal (ESR). Cultured B16 melanoma cells revealed a marked disturbance of cell growth especially in the solution with a high dose of selenium. These results may indicate that selenium has an antitumorigenic effect on B16 melanoma cells.
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