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ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL IDENTIFICATION OF MALIGNANT SCHWANNOMA OF THE SKIN
Author(s) -
Nomiyama Tomohiko,
Hornstein Otto P.
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb02883.x
Subject(s) - pathology , schwannoma , immunohistochemistry , ultrastructure , myofibroblast , neoplasm , histology , electron microscope , schwann cell , biology , medicine , physics , optics , fibrosis
Histogenetic identification of poorly differentiated spindle cell tumours can be very difficult if only routine histology is used. In the case of a 64‐year‐old man suffering from a recurrent and spreading malignant tumour on his neck, the precise diagnosis of malignant schwannoma was not established until a skin node was examined by electron microscopy. The neurogenic nature of the neoplasm was additionally confirmed by demonstration of S 100 protein within most of the tumour cells. Ultrastructurally, the tumour was composed predominantly of atypical Schwann cells and, in varying number, of perineurial cells, endoneurial cells and some myofibroblasts exhibiting features enabling their differentiation. Some electron microscopical findings not previously reported in malignant schwannoma were detailed.