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mRNA ACTIVITY OF M‐TYPE LACTATE DEHYDROGENASE IN DERMATOFIBROSARCOMA PROTUBERANS
Author(s) -
Ozasa Hisashi,
Shindo Yasuko
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb02882.x
Subject(s) - dermatofibrosarcoma protuberans , lactate dehydrogenase , sarcoma , messenger rna , enzyme , enzyme assay , microbiology and biotechnology , biology , chemistry , pathology , biochemistry , medicine , gene
The enzyme activity and mRNA level of M‐type lactate dehydrogenase (LDH) were studied in dermatofibrosarcoma protuberans (DFSP), a low grade sarcoma of the skin with a long clinical course and pronounced tendency toward progression and local recurrence. The isoenzyme pattern of LDH in DFSP was quite similar to that of other malignant skin tumors. The total LDH activity, ratio of M‐type activity, and mRNA level of M‐type LDH in DFSP were higher than those in control skin. It is suggested that this higher enzyme activity of M‐type LDH in DFSP was mainly due to the higher activity of mRNA coding for M‐type LDH.