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NEUTROPHIL MIGRATION IN GRANULOMA ANNULARE: COMPARATIVE STUDY BETWEEN LOCALIZED AND GENERALIZED TYPES AND BETWEEN ACTIVE AND REGRESSIVE STATES
Author(s) -
FriedmanBirnbaum Rachel,
Bergman Reuven,
Obedeanu Nora,
Meshulam Tova,
Merzbach David
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb02872.x
Subject(s) - chemotaxis , granuloma annulare , in vitro , immunology , disease , medicine , biology , genetics , receptor
ABSTRACT In vitro neutrophilic leukocyte (NL) chemotaxis was studied in patients with granuloma annulare (GA). Chemotaxis of NL from patients with the generalized form of the disease (GGA) was compared to that from patients with the localized form (LGA). A similar comparison was also made between patients in the active state of the disease versus those in regression. No significant differences were observed between any of the GA patients' values and a matched control group, nor were the observed differences statistically significant when NL migration was compared in patients with GGA versus LGA or in patients having the active form of the disease as compared to those in regression. In an attempt to detect eventual effects of control sera on patients' NL or of patients' sera on control NL, the sera and leukocytes were cross‐reacted in chemotactic assays. The results did not show any effect of crossing sera and cells. Taken together, these data fail to indicate any possible role for NL chemotactic activity in GA.