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NADPH OXIDASE AND MYELOPEROXIDASE ACTIVITY IN PSORIASIS LEUKOCYTES
Author(s) -
Jain Vijay K.,
Gupta Vipin,
Verma K.C.,
Saini A.S.
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb02867.x
Subject(s) - myeloperoxidase , nadph oxidase , psoriasis , enzyme , oxidase test , peroxidase , medicine , immunology , chemistry , biochemistry , inflammation
The levels of NADPH oxidase and myeloperoxidase activities in leukocytes of twenty psoriatics were significantly raised over those of controls. Psoriatics were divided into three grades by the rule of nine: Grade I—less than 33% skin involvement, Grade II—33–66% and Grade III—over 66% involvement. A definite relationship between the percentage of surface area involved and level of the two activities was noted. They were elevated over control levels in all grades except for NADPH oxidase in grade I. There were significant increases in the activities of both enzymes in grade II as compared with grade I.