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BULLOUS DERMATOSIS OF HEMODIALYSIS
Author(s) -
Matarredona Jaime,
Martín Roberto,
De Salamanca Rafael Enriquez,
Sendagorta Enrique,
Matesanz Rafael,
Perpiña Julia,
Ortuño Joaquín,
Ledo Antonio
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb02864.x
Subject(s) - porphyria cutanea tarda , hemodialysis , urine , medicine , porphyria , etiology , chronic renal failure , dermatology , uroporphyrinogen iii decarboxylase , feces , pathology , porphyrin , gastroenterology , bullous pemphigoid , chemistry , biology , immunology , heme , biochemistry , microbiology and biotechnology , enzyme , antibody
Bullous dermatosis developed in three patients with renal failure who were on maintenance hemodialysis. On clinical and histological grounds, skin lesions were indistinguishable from those of porphyria cutanea tarda. A highly sensitive fluorimetric thin‐layer chromatographic technique was used for assay of porphyrin levels in plasma, urine, feces and dialysate. The porphyrin metabolism alterations observed in our three patients were not sufficiently uniform to be considered the cause of the bullous dermatosis. Uroporphyrinogen decarboxylase activities in red cells were also within normal limits. No other common etiological factors could be identified in our patients.