Premium
DEMONSTRATION OF EOSINOPHIL CHEMOTACTIC FACTOR IN THE BLISTER FLUID OF PATIENT WITH INCONTINENTIA PIGMENTI
Author(s) -
Tsuda Shingo,
Higuchi Mitsunari,
Ichiki Mikio,
Sasai Yoichiro
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb02855.x
Subject(s) - incontinentia pigmenti , eosinophil , eosinophilia , chemotaxis , suction blister , suction , pathology , medicine , immunology , dermatology , chemistry , surgery , asthma , mechanical engineering , receptor , engineering
A case of incontinentia pigmenti associated with tissue and peripheral blood eosinophilia was reported. Eosinophil chemotactic factor (ECF) with low molecular weight was detected in the blister fluid at 17 days after birth by an in vitro chemotactic assay. ECF showed two different molecular weights; one was approximately 1355 daltons and the other much smaller. A similar factor was also detected in the content of a suction blister in clinically uninvolved skin at 2 months after birth. Investigations of ECF generation appears to be important in understanding of this disease.