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DRUG‐INDUCED LYMPHOCYTE PROLIFERATION IN THE EXPERIMENTAL SULBENICILLIN (SBPC) RASH OF GUINEA PIGS AND THE ENHANCEMENT EFFECTS OF INTERLEUKIN 2 (IL2)
Author(s) -
Ikezawa Zenro,
Aihara Michiko,
Nagai Ryukichi
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb02844.x
Subject(s) - medicine , immunology , interleukin , lymphocyte , interleukin 2 , pharmacology , drug , rash , immune system , cytokine
The effects of interleukin 2 (IL2) on drug‐specific lymphocyte proliferative responses and their suppression by elicitation of sulbenicillin (SBPC) rash and by induction of SBPC tolerance were studied. GR‐LC and TO‐LC, the draining lymph node cells taken from animals with SBPC generalized rash (GR) and SBPC tolerance (TO), respectively, were incubated with IL2 rich medium (IL2RM) overnight, then washed, and tested for antigen‐specific response in a standard 3‐day proliferation assay. The GR‐LC and TO‐LC showed low responsiveness or unresponsiveness to specific drug before overnight incubation with IL2LM, but recovered a distinct responsiveness after overnight incubation with IL2LM. This result is encouraging for the establishment of the drug‐specific lymphocyte proliferation test for determination of the causative drug in patients with delayed type hypersensitivity drug eruptions.