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CORRELATION OF MORPHOLOGICAL, BACTERIOLOGICAL, HISTOPATHOLOGICAL AND IMMUNOLOGICAL FEATURE OF LEPROSY
Author(s) -
Sehgal Virender Nath,
Koranne Ravindra Vishnu,
Sehgal Sunil,
Beoher Prakash Chand,
Sharma Viray Kumar
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb01569.x
Subject(s) - leprosy , subclinical infection , medicine , correlation , pathology , dermatology , mathematics , geometry
Fifty untreated and uncomplicated leprosy patients comprising three with TT, twenty‐six with BT, ten with BB, four with BL and seven with LL formed the subject material for the study. They were subjected to detailed morphological, bacteriological, histopathological and immunological investigations. Four investigators undertook the study and each one independently investigated one parameter according to a pre‐conceived standard set. The data were pooled and analysed after breaking the code. A good correlation amongst all four parameters was seen only in 44%. A striking variation in three other parameters was found in 56%, primarily in the borderline groups suggesting subclinical bacteriological, histopathological and immunological instability, either in the form of upgrading or downgrading. Similarly, the separation of five indeterminate cases from those of BT group was intriguing.