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CUTANEOUS MALIGNANT LYMPHOMA AND HLA IN THE SOUTHWESTERN AREA OF JAPAN
Author(s) -
Yotsumoto Hideaki,
Tashiro Masaaki,
Shimokawa Yuko,
Asai Hitomi,
Nomoto Shigeru
Publication year - 1985
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1985.tb01550.x
Subject(s) - lymphoma , malignant lymphoma , human leukocyte antigen , medicine , leukemia , disease , pathology , oncology , antigen , dermatology , immunology
Recently, classification of malignant lymphoreticular tumors have been reevaluated and various new disease entities have been proposed. Patients with T cell lymphoma, including adult T cell leukemia/lymphoma (ATLL), are very frequent in the southwestern area of Japan. To investigate the role of genetic factors in patients with cutaneous malignant lymphoma (CML), which has a T cell nature, from an endemic area of ATLL, we studied the association between HLA and CML within this area. The frequency of AW24 in CML patients was reduced. AW33 and BW61 were increased in frequency in these patients. However, none of the P values mentioned remained significant after correction for the number of antigens tested. Haplotypes of AW24‐BW61, AW26‐BW61 and AW33‐BW61 were increased in frequency in CML patients.