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IMMUNE COMPLEXES AND LYMPHOCYTE SUBSET IN SECONDARY STAGE PITYRIASIS ROSEA #
Author(s) -
Wu YingChin,
Chang ChunHsiang,
Hsieh RhongPhong,
In KuoLin
Publication year - 1984
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1984.tb01522.x
Subject(s) - pityriasis rosea , immunology , immune system , pathogenesis , antibody , cytotoxic t cell , lymphocyte , inducer , suppressor , medicine , biology , in vitro , gene , biochemistry , cancer
Circulating immune complexes (CIC), percentages of lymphocyte subsets, serum immunoglobulins (IgG, M, A), serum complements (C3, C4) and tissue immunoreactants (IgG, M, A, C3, Clq, properdin and fibrinogen) were measured in thirty‐one patients with secondary stage pityriasis rosea (PR) and in forty‐five healthy controls. In these patients, no significant amount of CIC and tissue immunoreactants were detected. Decreased OKT4/OKT8 ratio resulting from the decreased OKT4‐positive (helper/inducer) cells and the increased OKT8‐positive (suppressor/cytotoxic) cells was noted in the patients as compared with the controls (p<0.001). In addition, an elevation of IgM and a decrease of C3 in sera were also noted. The role of the immune mechanism in the pathogenesis of PR and the possible causal agents are discussed.