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THE ROLE OF POLYMORPHONUCLEAR CELLS IN PSORIASIS
Author(s) -
Tosca A.,
Varelzidis A.,
Kavadda H.,
Michalopoulos M.,
Hatzis J.,
Stratigos J.
Publication year - 1984
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1984.tb01488.x
Subject(s) - phagocytosis , zymosan , psoriasis , chemotaxis , candida albicans , immunology , polymorphonuclear leukocyte , granulocyte , medicine , chemistry , microbiology and biotechnology , biology , in vitro , receptor , biochemistry
Neutrophil cell function in psoriasis was studied through polymorphonuclear cell adherence to nylon wool, chemotaxis under agarose, and phagocytosis of Candida albicans . Differences in PMN adherence were not found between psoriatics and controls. The chemotactic response to zymosan activated serum (ZAS) did not differ between psoriatic and normal PMNs. The psoriatic serum exhibited chemoattracting properties equal to ZAS. Psoriatic serum was shown to be chemoattracting to psoriatic and normal PMNs whereas normal serum was only to psoriatic cells. Differences in recognition mechanisms between psoriatic and normal cells are proposed. Phagocytosis of Candida by psoriatic PMNS was earlier and more prolonged and candidacidal activity was earlier and definetely increased at given times compared to normal PMNs. A protective role of psoriatic PMNs in Munro's microabcesses against bacterial invasion is postulated.