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DISTURBED MITOTIC PROCESSES OF STROMA CELLS IN A PATIENT WITH TUBEROUS SCLEROSIS
Author(s) -
Ishibashi Yasumasa,
Inoue Yukiko,
Takehara Kazuhiko,
Furue Masutaka,
Kukita Atsushi
Publication year - 1984
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1984.tb01472.x
Subject(s) - mitosis , cell division , biology , microtubule , microbiology and biotechnology , metaphase , tuberous sclerosis , anaphase , chromosome , anatomy , pathology , cell , cell cycle , genetics , medicine , gene
Skin fragments of a giant molluscum pendulum and so‐called adenomata sebacea (AS) in the face of a 21‐year‐old female with Pringle's disease were explanted and the cell divisions of outgrown and subcultured non‐epithelial cells (NECs) were observed at suitable intervals with a phase contrast microscope. In both tissues, a number of NECs, especially large and medium sized ones, showed distinct chromosome dysarrangements, including segmental arrangement, eccentric arrangement, and arrangement failure, when chromosomes were arranged in the central area of individual cells in metaphase, causing extreme lagging in the subsequent cell division. These cells showed varying disturbances such as 1) the formation of elevated humps of varying sizes, followed by division after some of them were eliminated, 2) division into two cells of different sizes, 3) division into three after microcells had formed, 4) division into several, which was followed by restitution into two by fusion, 5) division failure, and 6) multinucleation after division, all of which suggested C‐mitosis. These findings indicate that the distributing mechanism of chromosomes, i.e. the centromere‐microtubules‐centriole system, particularly the function of microtubules, might be disturbed in the NECs.