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BIOCHEMICAL STUDY ON GANGLIOSIDES IN NEURO‐FIBROMAS AND NEUROFIBROSARCOMAS OF RECKLINGHAUSEN'S DISEASE
Author(s) -
Tsuchida Tetsuya,
Otsuka Hideaki,
Niimura Michihito,
Inoue Yukiko,
Kukita Atsushi,
Hashimoto Yasuhiro,
Seyama Yousuke,
Yamakawa Tamio
Publication year - 1984
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1984.tb01454.x
Subject(s) - neurofibroma , ganglioside , plexiform neurofibroma , sciatic nerve , pathology , myelin , neurilemoma , chemistry , biology , biochemistry , medicine , anatomy , schwannoma , neuroscience , neurofibromatosis , central nervous system
Gangliosides in neurofibromas and neurofibrosarcomas of Recklinghausen's disease and those of neurilemmomas of non Recklinghausen's disease were investigated. Two types of neurofibromas, cutaneous neurofibromas and plexiform neurofibromas, which are considered to originate from Schwann cells and endoneural fibroblasts, showed almost similar ganglioside compositions; both types contained GM3, GD3, GD1a, GD1b and GT1b as the major gangliosides. These ganglioside compositions resembled those of normal whole sciatic nerve, but not those of the myelin of a normal sciatic nerve hitherto reported. The ganglioside compositions of neurilemmomas, which are also considered to be derived from Schwann cells, resembled those of sciatic nerve myelin. In neurofibrosarcomas, the content of gangliosides with longer carbohydrate chains was remarkably decreased, but not in neurofibromas. This finding indicated that the biochemical analysis of ganglioside compositions of such tumors may be a useful tool for the diagnosis of the malignancy of diseases. Major gangliosides extracted from a big plexiform neurofibroma were identified by TLC, GLC and neuraminidase treatment.