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IMMUNOCYTOCHEMICAL STUDIES ON INFLAMMATORY INFILTRATES IN PSORIASIS
Author(s) -
Kaneko Fumio,
Kawagishi Ikuro,
Miura Yusho,
Watanabe Makoto,
Kishiyama Kazunori,
Ohkawara Akira
Publication year - 1984
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1984.tb01444.x
Subject(s) - dermis , psoriasis , stratum corneum , pathology , immune system , inflammation , antibody , epidermis (zoology) , chemistry , medicine , immunology , biology , anatomy
Deposits of immunoglobulins (Igs) and complement components can be demonstrated in the stratum corneum (SC) of psoriatic lesions by immunofluorescent (IF) technique. In this paper, the underlying inflammation in the lesional dermis, which may affect the immune reactions in the SC, was investigated by immunocytochemical and IF techniques. Using the reactive tests for α‐naphthyl acetate esterase (ANAE) activity, T‐lymphocytes were found to be predominant among inflammatory infiltrates in the lesional dermis. By the immunoperoidase method, IgA and secretory component (S‐component) bearing cells, which seemed to be bound to each other on their cell surfaces, comprised about 20% of the mass of infiltrates in the upper dermis of early psoriatic lesions. These Igs and S‐component bearing cells seemed to be non T‐lymphocytes. The inflammatory conditions in the dermis appeared to be closely connected to the immune reactions in the SC of psoriasis.