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MIXED SKIN CELL LYMPHOCYTE CULTURE REACTION (MSLR) IN PSORIASIS
Author(s) -
Faure M.,
Czernielewski J.,
Schmitt D.,
Thivolet J.
Publication year - 1983
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1983.tb01183.x
Subject(s) - psoriasis , stimulation , immunology , lymphocyte , in vitro , epidermis (zoology) , medicine , peripheral blood mononuclear cell , biology , endocrinology , biochemistry , anatomy
The Mixed Skin Cell Lymphocyte Culture Reaction (MSLR) was studied as an in vitro approach of lympho‐epidermal interactions in psoriasis. The ability of peripheral blood lymphocytes from patients with psoriasis to proliferate in response to stimulation by epidermal cells and the capacity of psoriatic epidermal cells to stimulate T cells were investigated and compared to results with cells from controls. While stimulation of control lymphocytes by autologous epidermal cells was observed, although weaker than the proliferation in response to allogeneic control epidermal cells, no stimulation was observed in autologous MSLR using psoriatic cells. The ability of epidermal cells from psoriatic skin, either uninvolved or involved skin, to induce proliferation of control lymphocytes in allogeneic MSLR did not differ from that of control epidermal cells. In contrast with results obtained with control lymphocytes and epidermal cells in allogeneic MSLR, peripheral blood cells from psoriatic subjects failed to react to stimulation by control allogeneic epidermal cells. These results indicate a normal capacity of psoriatic epidermal cells to stimulate in MSLR and a functional inability of peripheral blood lymphocytes from patients with psoriasis to react in MSLR which is in agreement with previous reports of abnormal T cell functions in the disease.