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FAILURE TO DETECT β 2 MICROGLOBULIN IN VIRAL WARTS
Author(s) -
Furue Masutaka,
Inoue Yukiko
Publication year - 1983
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1983.tb01165.x
Subject(s) - stratum spinosum , beta 2 microglobulin , epidermodysplasia verruciformis , immunoperoxidase , immunofluorescence , cell , stratum corneum , keratinocyte , biology , virology , virus , pathology , medicine , immunology , cell culture , antibody , genetics , monoclonal antibody
Twenty warts including Tinea versicolor like lesions of epidermodysplasia verruciformis were examined for cell membrane associated β 2 microglobulin by the use of the direct immunofluorescence and indirect immunoperoxidase technique. The human papilloma virus infected keratinocytes in the granular layer and the uppermost stratum spinosum lack immunoreactive β 2 microglobulin on the cell surface. This finding indicates that the human papilloma virus does alter the cell membrane properties of the infected target keratinocyte, and the failure to detect β 2 microglobulin on cell surface does not necessarily mean that these cells have undergone malignant transformation.