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ACQUIRED COLD URTICARIA
Author(s) -
Katayama Ichiro,
Doi Toshiaki,
Nishioka Kiyoshi,
Maeyama Kazutaka,
Yamatodani Atsushi
Publication year - 1983
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1983.tb01152.x
Subject(s) - cyproheptadine , cimetidine , histamine , antagonist , medicine , diphenhydramine , pharmacology , edema , histamine h1 receptor , histamine h2 receptor , drug , receptor , serotonin
Three patients with idiopathic cold urticaria were treated with either or both cyproheptadine (Histamine H 1 receptor antagonist) and cimetidine (Histamine H 2 receptor antagonist). Cold induced histamine release (CIHR) was significantly higher in the patients (71.0 ± 23.8 pm/ml) than in normal volunteers (4.5 ± 1.0 pm/ml). Improvement of clinical manifestations with reduced CIHR was obtained by combination therapy using cyproheptadine and cimetidine but no favorable response was noted with either drug alone. The combined therapy with both drugs completely suppressed pruritis and edema but failed to suppress the erythematous reaction. Single cyproheptadine therapy was rather favored by the patients despite positive CIHR with the therapy. Histamine release from patients' leukocytes under three different conditions (37°C, 4°C→37°C, 4°C) was not significantly different.