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PENETRATION OF FRAGRANCE COMPOUNDS THROUGH HUMAN EPIDERMIS
Author(s) -
Jimbo Yuko
Publication year - 1983
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1983.tb01132.x
Subject(s) - penetration (warfare) , solubility , chemistry , octanol , benzyl alcohol , human skin , organic chemistry , chromatography , partition coefficient , biology , operations research , engineering , genetics , catalysis
Penetration through excised human epidermis of six phenolic, four benzyl, two salicylate and six cinnamic compounds was examined. A considerable difference in penetration of the compounds tested was observed. Benzyl alcohol penetrated most rapidly. Solubility in water and octanol of each compound was studied. All compounds were freely soluble in octanol. A high correlation between water solubility and percent penetration through human epidermis of compounds was observed. The percent penetration of compounds was not related to allergenic potency.