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IN VITRO STUDY OF CHLORPROMAZINE PHOTOSENSITIZATION: PHOTOINACTIVATION OF BACTERIOPHAGE RNA IN THE PRESENCE OF CHLORPROMAZINE
Author(s) -
Matsuo Itsuro,
Ohkido Muneo,
Fujita Hitoshi,
Kawano Katsumi,
Suzuki Kenshi
Publication year - 1983
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1983.tb01116.x
Subject(s) - chlorpromazine , rna , in vitro , escherichia coli , bacteriophage , chemistry , bacteriophage ms2 , infectivity , spheroplast , microbiology and biotechnology , biochemistry , biology , virology , pharmacology , virus , gene
Effects of chlorpromazine plus UVA‐illumination on RNA were studied in vitro . Chlorpromazine‐UVA treatment of RNA extracted from bacteriophages MS2 and Q β reduced their infectivity to Escherichia coli spheroplasts. Extent of the inactivation was increased with increasing concentrations of chlorpromazine and with increasing fluence of UVA. In the light of our previous findings, chlorpromazine‐adduct to purine residues is suggested as a possible source of damage leading to the inactivation of RNA.