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LICHEN PLANUS: EVALUATION OF CELLS IN SKIN LESIONS AND OF T‐LYMPHOCYTE SUBSETS IN BLOOD
Author(s) -
FernandezBussy Ramon A.,
Schmitt Daniel,
Gaucherand Martine,
Maudutt Gilles,
Gomes Manuel A.,
Brochier Jean,
Thivolet Jean
Publication year - 1983
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1983.tb01100.x
Subject(s) - cytotoxic t cell , epidermis (zoology) , monoclonal antibody , biology , immunology , phenotype , dermis , pathology , antibody , medicine , in vitro , biochemistry , anatomy , gene
The purpose of the present study was to examine the phenotype of cutaneous immunocompetent cells and to quantify Langerhans cells in Lichen planus by the use of monoclonal antibodies directed against T‐cell populations. Helper cells (OKT4+) and Suppressor/cytotoxic cells (OKT8+) were observed in all cutaneous infiltrates, and numerous Langerhans cells were identified by OKT6, BL6, and BL2 (HLA‐DR) in the epidermis and dermis. The quantification of Langerhans cells demonstrated that the number of dendritic cells in epidermis is greater in involved skin than in non‐involved skin. In recent lesions, Langerhans cells are more abundant than in older lesions. The results in peripheral blood indicated a T Helper/Suppressor imbalance with a decreased T‐Suppressor/cytotoxic subpopulation in patients with lichen planus diseases. In lichen planus, our results suggest an immunological reaction involving all the immunocompetent cell subpopulations with a first stage of information by Langerhans cells (OKT6+, BL6+, BL2+ (HLA‐DR)) and Helper cells (OKT4+), and second stage mediated by Suppressor/cytotoxic cells (OKT8+).