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YELLOW MACULES APPEARING DURING CORTICOSTEROID TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS
Author(s) -
Aso Miki,
Mihara Motoyuki,
Shimao Shuhei
Publication year - 1982
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1982.tb02627.x
Subject(s) - endoplasmic reticulum , ultrastructure , extracellular , corticosteroid , lupus erythematosus , pathology , amorphous solid , connective tissue disease , chemistry , medicine , endocrinology , immunology , autoimmune disease , biochemistry , crystallography , disease , antibody
A 42‐year‐old woman who had been treated with corticosteroid for systemic lupus erythematosus had many yellow macules on her extremities and body. Light microscopic examination revealed a decrease or disappearance of collagen fibers and the formation of abnormal fibers. Ultrastructural study showed that these abnormal fibers were numerous cord‐like substances related to extracellular amorphous or filamentous materials and similar to the amorphous materials in the rough endoplasmic reticulum of fibroblasts. It was suggested that fibroblasts injured by corticosteroid produced an abnormal precursor of collagen fiber and that the synthesis of normal collagen fibers was inhibited in the yellow macules.