Premium
EXPERIMENTAL DRUG‐INDUCED RASH AND SYSTEMIC CUTANEOUS BASOPHIL HYPERSENSITIVITY
Author(s) -
Kitamura Kazuko,
Ikezawa Zenro,
Murakami Junko,
Nagai Ryukichi
Publication year - 1982
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/j.1346-8138.1982.tb02621.x
Subject(s) - eosinophilia , medicine , basophilia , rash , infiltration (hvac) , cellular infiltration , dermatology , atypical lymphocyte , pathology , immunology , inflammation , peripheral blood , physics , thermodynamics
Guinea pigs immunized with antibiotics (sodium cephalothin, CET) developed a systemic, delayed‐onset rash or so called generalized rash (GR) when challenged intraperitoneally with large amounts of CET seven weeks later. Skin test reactivity and GR intensity were most prominent at 24 hours. Microscopically, skin test reactions and flare‐up lesions of old skin test sites during GR were characterized by the onset of dermal infiltration of lymphocytes, striking dilatation and compaction of superficial venules at 24 hours, and papillary dermal infiltration of basophils at 48 hours. In addition, the animals that developed GR exhibited eosinophilia at 24 hours, which was followed by basophilia at 48 hours. GR developed with large doses of CET has properties similar to the so called SCBH designated by H.F. Dvorak. This experimental model may serve as a useful model for drug reactions in man which may involve SCBH.